Produkte

CTP versetzt Dich innerhalb von Minuten auf sichere, natürliche und ungiftige Weise in einen Zustand bewusster Wahrnehmung, Aufmerksamkeit und Motivation. Dies geschieht über die Anregung und Aufrechterhaltung der Signalübertragung via cAMP (durch Artischocken- u. Buntnesselextrakt) sowie die stimulierenden und vor Erschöpfung schützenden Eigenschaften von Acetyl-L-Carnitin. Bei regelmäßiger Einnahme erreicht außerdem der Langzeiteffekt LTP (Long Term Potentiation) eine messbare, dauerhaft bessere Verdrahtung der in Lernvorgänge verwickelten Gehirnzellen. Zu Lernendes wird effektiver abgespeichert und ist schnell wiederaufrufbar. Ein Verbesserung von sozialen Skills und allgemeiner Stimmung sind weitere bemerkenswerte Aspekte, die sich bereits nach der ersten Einnahme einstellen können. Zur Sicherheit und Wirksamkeit der Komponenten existiert eine Vielzahl von Studien, das Produkt ist seit 2012 unter dem Namen CILTEP (Natural Stacks) in den USA auf dem Markt 

Tagesdosis: 2-5 Kapseln Einnahme vor dem Frühstück, Wirkdauer 10-14 Stunden

 

 

 

Inhaltsstoffe:

 

Artischockenextrakt

Buntnesselextrakt

Acetyl-L-Carnitin

L-Phenylalanin

Vitamin B6

 

Studien zu den Inhaltsstoffen:

Rutten K, Van donkelaar EL, Ferrington L, et al. Phosphodiesterase inhibitors enhance object memory independent of cerebral blood flow and glucose utilization in rats. Neuropsychopharmacology. 2009;34(8):1914-25. PMID 19262466

 

Egawa T, Mishima K, Matsumoto Y, Iwasaki K, Iwasaki K, Fujiwara M. Rolipram and its optical isomers, phosphodiesterase 4 inhibitors, attenuated the scopolamine-induced impairments of learning and memory in rats. Jpn J Pharmacol. 1997;75(3):275-81. PMID 9434259

 

Zhang HT, O'donnell JM. Effects of rolipram on scopolamine-induced impairment of working and reference memory in the radial-arm maze tests in rats. Psychopharmacology (Berl). 2000;150(3):311-6. PMID 10923759

 

Zhang HT, Crissman AM, Dorairaj NR, Chandler LJ, O'donnell JM. Inhibition of cyclic AMP phosphodiesterase (PDE4) reverses memory deficits associated with NMDA receptor antagonism. Neuropsychopharmacology. 2000;23(2):198-204. PMID 10882846

 

Zhang HT, Huang Y, Suvarna NU, et al. Effects of the novel PDE4 inhibitors MEM1018 and MEM1091 on memory in the radial-arm maze and inhibitory avoidance tests in rats. Psychopharmacology (Berl). 2005;179(3):613-9. PMID 15672274

 

Mclean JH, Smith A, Rogers S, Clarke K, Darby-king A, Harley CW. A phosphodiesterase inhibitor, cilomilast, enhances cAMP activity to restore conditioned odor preference memory after serotonergic depletion in the neonate rat. Neurobiol Learn Mem. 2009;92(1):63-9. PMID 19233302

 

Wang C, Yang XM, Zhuo YY, et al. The phosphodiesterase-4 inhibitor rolipram reverses Aβ-induced cognitive impairment and neuroinflammatory and apoptotic responses in rats. Int J Neuropsychopharmacol. 2012;15(6):749-66. PMID 21733236

 

Rose GM, Hopper A, De vivo M, Tehim A. Phosphodiesterase inhibitors for cognitive enhancement. Curr Pharm Des. 2005;11(26):3329-34. PMID 16250839

 

Drott J, Desire L, Drouin D, Pando M, Haun F. Etazolate improves performance in a foraging and homing task in aged rats. Eur J Pharmacol. 2010;634(1-3):95-100. PMID 20223232

 

Li LX, Cheng YF, Lin HB, Wang C, Xu JP, Zhang HT. Prevention of cerebral ischemia-induced memory deficits by inhibition of phosphodiesterase-4 in rats. Metab Brain Dis. 2011;26(1):37-47. PMID 21327879

 

Gallant M, Aspiotis R, Day S, et al. Discovery of MK-0952, a selective PDE4 inhibitor for the treatment of long-term memory loss and mild cognitive impairment. Bioorg Med Chem Lett. 2010;20(22):6387-93. PMID 20933411

 

Heaslip RJ, Evans DY. Emetic, central nervous system, and pulmonary activities of rolipram in the dog. Eur J Pharmacol. 1995;286(3):281-90. PMID 8608790

 

Bruno O, Fedele E, Prickaerts J, et al. GEBR-7b, a novel PDE4D selective inhibitor that improves memory in rodents at non-emetic doses. Br J Pharmacol. 2011;164(8):2054-63. PMID 21649644

 

Mackenzie SJ, Houslay MD. Action of rolipram on specific PDE4 cAMP phosphodiesterase isoforms and on the phosphorylation of cAMP-response-element-binding protein (CREB) and p38 mitogen-activated protein (MAP) kinase in U937 monocytic cells. Biochem J. 2000;347(Pt 2):571-8. 10749688

 

Xu W, Kasper LH, Lerach S, Jeevan T, Brindle PK. Individual CREB-target genes dictate usage of distinct cAMPresponsive coactivation mechanisms. EMBO J. 2007;26(12):2890-903. PMID 17525731

 

Benito E, Valor LM, Jimenez-minchan M, Huber W, Barco A. cAMP response element-binding protein is a primary hub of activity-driven neuronal gene expression. J Neurosci. 2011;31(50):18237-50. PMID 22171029

 

Lee J, Kim CH, Simon DK, et al. Mitochondrial cyclic AMP response element-binding protein (CREB) mediates mitochondrial gene expression and neuronal survival. J Biol Chem. 2005;280(49):40398-401. PMID 16207717

 

Deisseroth K, Bito H, Tsien RW. Signaling from synapse to nucleus: postsynaptic CREB phosphorylation during multiple forms of hippocampal synaptic plasticity. Neuron. 1996;16(1):89-101. PMID 8562094

 

Kida S. A Functional Role for CREB as a Positive Regulator of Memory Formation and LTP. Exp Neurobiol. 2012;21(4):136-40. PMID 23319873

 

Suzuki A, Fukushima H, Mukawa T, et al. Upregulation of CREB-mediated transcription enhances both short- and long-term memory. J Neurosci. 2011;31(24):8786-802. PMID 21677163

 

Ammon HP, Müller AB. Forskolin: from an ayurvedic remedy to a modern agent. Planta Med. 1985;51(6):473-7. PMID 17345261

 

Seamon KB, Daly JW. Forskolin: a unique diterpene activator of cyclic AMP-generating systems. J Cyclic Nucleotide Res. 1981;7(4):201-24. PMID 6278005

 

Barad M, Bourtchouladze R, Winder DG, Golan H, Kandel E. Rolipram, a type IV-specific phosphodiesterase inhibitor, facilitates the establishment of long-lasting long-term potentiation and improves memory. Proc Natl Acad Sci USA. 1998;95(25):15020-5. PMID 9844008

 

Yu MC, Chen JH, Lai CY, Han CY, Ko WC. Luteolin, a non-selective competitive inhibitor of phosphodiesterases 1- 5, displaced [3H]-rolipram from high-affinity rolipram binding sites and reversed xylazine/ketamine-induced anesthesia. Eur J Pharmacol. 2010;627(1-3):269-75. PMID 19853596

 

Brown JE, Rice-evans CA. Luteolin-rich artichoke extract protects low density lipoprotein from oxidation in vitro. Free Radic Res. 1998;29(3):247-55. PMID 9802556

 

Kitagawa Y, Hirano T, Kawaguchi SY. Prediction and validation of a mechanism to control the threshold for inhibitory synaptic plasticity. Mol Syst Biol. 2009;5:280. PMID 19536203

 

Puzzo D, Sapienza S, Arancio O, Palmeri A. Role of phosphodiesterase 5 in synaptic plasticity and memory. Neuropsychiatr Dis Treat. 2008;4(2):371-87. PMID 18728748

 

Otmakhov N, Khibnik L, Otmakhova N, et al. Forskolin-induced LTP in the CA1 hippocampal region is NMDA receptor dependent. J Neurophysiol. 2004;91(5):1955-62. PMID 14702333

 

Piech-dumas KM, Tank AW. CREB mediates the cAMP-responsiveness of the tyrosine hydroxylase gene: use of an antisense RNA strategy to produce CREB-deficient PC12 cell lines. Brain Res Mol Brain Res. 1999;70(2):219-30. PMID 10407170

 

Kumer SC, Vrana KE. Intricate regulation of tyrosine hydroxylase activity and gene expression. J Neurochem. 1996;67(2):443-62. PMID 8764568

 

White HL, Scates PW. Acetyl-L-carnitine as a precursor of acetylcholine. Neurochem Res. 1990;15(6):597-601. PMID 2215852

CTP versetzt Dich innerhalb von Minuten auf sichere, natürliche und ungiftige Weise in einen Zustand bewusster Wahrnehmung, Aufmerksamkeit und Motivation. Dies geschieht über die Anregung und Aufrechterhaltung der Signalübertragung via cAMP (durch Artischocken- u. Buntnesselextrakt) sowie die stimulierenden und vor Erschöpfung schützenden Eigenschaften von Acetyl-L-Carnitin. Bei regelmäßiger Einnahme erreicht außerdem der Langzeiteffekt LTP (Long Term Potentiation) eine messbare, dauerhaft bessere Verdrahtung der in Lernvorgänge verwickelten Gehirnzellen. Zu Lernendes wird effektiver abgespeichert und ist schnell wiederaufrufbar. Ein Verbesserung von sozialen Skills und allgemeiner Stimmung sind weitere bemerkenswerte Aspekte, die sich bereits nach der ersten Einnahme einstellen können. Zur Sicherheit und Wirksamkeit der Komponenten existiert eine Vielzahl von Studien, das Produkt ist seit 2012 unter dem Namen CILTEP (Natural Stacks) in den USA auf dem Markt 

Tagesdosis: 2-5 Kapseln Einnahme vor dem Frühstück, Wirkdauer 10-14 Stunden

 

 

 

Inhaltsstoffe:

 

Artischockenextrakt

Buntnesselextrakt

Acetyl-L-Carnitin

L-Phenylalanin

Vitamin B6

 

Studien zu den Inhaltsstoffen:

Rutten K, Van donkelaar EL, Ferrington L, et al. Phosphodiesterase inhibitors enhance object memory independent of cerebral blood flow and glucose utilization in rats. Neuropsychopharmacology. 2009;34(8):1914-25. PMID 19262466

 

Egawa T, Mishima K, Matsumoto Y, Iwasaki K, Iwasaki K, Fujiwara M. Rolipram and its optical isomers, phosphodiesterase 4 inhibitors, attenuated the scopolamine-induced impairments of learning and memory in rats. Jpn J Pharmacol. 1997;75(3):275-81. PMID 9434259

 

Zhang HT, O'donnell JM. Effects of rolipram on scopolamine-induced impairment of working and reference memory in the radial-arm maze tests in rats. Psychopharmacology (Berl). 2000;150(3):311-6. PMID 10923759

 

Zhang HT, Crissman AM, Dorairaj NR, Chandler LJ, O'donnell JM. Inhibition of cyclic AMP phosphodiesterase (PDE4) reverses memory deficits associated with NMDA receptor antagonism. Neuropsychopharmacology. 2000;23(2):198-204. PMID 10882846

 

Zhang HT, Huang Y, Suvarna NU, et al. Effects of the novel PDE4 inhibitors MEM1018 and MEM1091 on memory in the radial-arm maze and inhibitory avoidance tests in rats. Psychopharmacology (Berl). 2005;179(3):613-9. PMID 15672274

 

Mclean JH, Smith A, Rogers S, Clarke K, Darby-king A, Harley CW. A phosphodiesterase inhibitor, cilomilast, enhances cAMP activity to restore conditioned odor preference memory after serotonergic depletion in the neonate rat. Neurobiol Learn Mem. 2009;92(1):63-9. PMID 19233302

 

Wang C, Yang XM, Zhuo YY, et al. The phosphodiesterase-4 inhibitor rolipram reverses Aβ-induced cognitive impairment and neuroinflammatory and apoptotic responses in rats. Int J Neuropsychopharmacol. 2012;15(6):749-66. PMID 21733236

 

Rose GM, Hopper A, De vivo M, Tehim A. Phosphodiesterase inhibitors for cognitive enhancement. Curr Pharm Des. 2005;11(26):3329-34. PMID 16250839

 

Drott J, Desire L, Drouin D, Pando M, Haun F. Etazolate improves performance in a foraging and homing task in aged rats. Eur J Pharmacol. 2010;634(1-3):95-100. PMID 20223232

 

Li LX, Cheng YF, Lin HB, Wang C, Xu JP, Zhang HT. Prevention of cerebral ischemia-induced memory deficits by inhibition of phosphodiesterase-4 in rats. Metab Brain Dis. 2011;26(1):37-47. PMID 21327879

 

Gallant M, Aspiotis R, Day S, et al. Discovery of MK-0952, a selective PDE4 inhibitor for the treatment of long-term memory loss and mild cognitive impairment. Bioorg Med Chem Lett. 2010;20(22):6387-93. PMID 20933411

 

Heaslip RJ, Evans DY. Emetic, central nervous system, and pulmonary activities of rolipram in the dog. Eur J Pharmacol. 1995;286(3):281-90. PMID 8608790

 

Bruno O, Fedele E, Prickaerts J, et al. GEBR-7b, a novel PDE4D selective inhibitor that improves memory in rodents at non-emetic doses. Br J Pharmacol. 2011;164(8):2054-63. PMID 21649644

 

Mackenzie SJ, Houslay MD. Action of rolipram on specific PDE4 cAMP phosphodiesterase isoforms and on the phosphorylation of cAMP-response-element-binding protein (CREB) and p38 mitogen-activated protein (MAP) kinase in U937 monocytic cells. Biochem J. 2000;347(Pt 2):571-8. 10749688

 

Xu W, Kasper LH, Lerach S, Jeevan T, Brindle PK. Individual CREB-target genes dictate usage of distinct cAMPresponsive coactivation mechanisms. EMBO J. 2007;26(12):2890-903. PMID 17525731

 

Benito E, Valor LM, Jimenez-minchan M, Huber W, Barco A. cAMP response element-binding protein is a primary hub of activity-driven neuronal gene expression. J Neurosci. 2011;31(50):18237-50. PMID 22171029

 

Lee J, Kim CH, Simon DK, et al. Mitochondrial cyclic AMP response element-binding protein (CREB) mediates mitochondrial gene expression and neuronal survival. J Biol Chem. 2005;280(49):40398-401. PMID 16207717

 

Deisseroth K, Bito H, Tsien RW. Signaling from synapse to nucleus: postsynaptic CREB phosphorylation during multiple forms of hippocampal synaptic plasticity. Neuron. 1996;16(1):89-101. PMID 8562094

 

Kida S. A Functional Role for CREB as a Positive Regulator of Memory Formation and LTP. Exp Neurobiol. 2012;21(4):136-40. PMID 23319873

 

Suzuki A, Fukushima H, Mukawa T, et al. Upregulation of CREB-mediated transcription enhances both short- and long-term memory. J Neurosci. 2011;31(24):8786-802. PMID 21677163

 

Ammon HP, Müller AB. Forskolin: from an ayurvedic remedy to a modern agent. Planta Med. 1985;51(6):473-7. PMID 17345261

 

Seamon KB, Daly JW. Forskolin: a unique diterpene activator of cyclic AMP-generating systems. J Cyclic Nucleotide Res. 1981;7(4):201-24. PMID 6278005

 

Barad M, Bourtchouladze R, Winder DG, Golan H, Kandel E. Rolipram, a type IV-specific phosphodiesterase inhibitor, facilitates the establishment of long-lasting long-term potentiation and improves memory. Proc Natl Acad Sci USA. 1998;95(25):15020-5. PMID 9844008

 

Yu MC, Chen JH, Lai CY, Han CY, Ko WC. Luteolin, a non-selective competitive inhibitor of phosphodiesterases 1- 5, displaced [3H]-rolipram from high-affinity rolipram binding sites and reversed xylazine/ketamine-induced anesthesia. Eur J Pharmacol. 2010;627(1-3):269-75. PMID 19853596

 

Brown JE, Rice-evans CA. Luteolin-rich artichoke extract protects low density lipoprotein from oxidation in vitro. Free Radic Res. 1998;29(3):247-55. PMID 9802556

 

Kitagawa Y, Hirano T, Kawaguchi SY. Prediction and validation of a mechanism to control the threshold for inhibitory synaptic plasticity. Mol Syst Biol. 2009;5:280. PMID 19536203

 

Puzzo D, Sapienza S, Arancio O, Palmeri A. Role of phosphodiesterase 5 in synaptic plasticity and memory. Neuropsychiatr Dis Treat. 2008;4(2):371-87. PMID 18728748

 

Otmakhov N, Khibnik L, Otmakhova N, et al. Forskolin-induced LTP in the CA1 hippocampal region is NMDA receptor dependent. J Neurophysiol. 2004;91(5):1955-62. PMID 14702333

 

Piech-dumas KM, Tank AW. CREB mediates the cAMP-responsiveness of the tyrosine hydroxylase gene: use of an antisense RNA strategy to produce CREB-deficient PC12 cell lines. Brain Res Mol Brain Res. 1999;70(2):219-30. PMID 10407170

 

Kumer SC, Vrana KE. Intricate regulation of tyrosine hydroxylase activity and gene expression. J Neurochem. 1996;67(2):443-62. PMID 8764568

 

White HL, Scates PW. Acetyl-L-carnitine as a precursor of acetylcholine. Neurochem Res. 1990;15(6):597-601. PMID 2215852

CTP versetzt Dich innerhalb von Minuten auf sichere, natürliche und ungiftige Weise in einen Zustand bewusster Wahrnehmung, Aufmerksamkeit und Motivation. Dies geschieht über die Anregung und Aufrechterhaltung der Signalübertragung via cAMP (durch Artischocken- u. Buntnesselextrakt) sowie die stimulierenden und vor Erschöpfung schützenden Eigenschaften von Acetyl-L-Carnitin. Bei regelmäßiger Einnahme erreicht außerdem der Langzeiteffekt LTP (Long Term Potentiation) eine messbare, dauerhaft bessere Verdrahtung der in Lernvorgänge verwickelten Gehirnzellen. Zu Lernendes wird effektiver abgespeichert und ist schnell wiederaufrufbar. Ein Verbesserung von sozialen Skills und allgemeiner Stimmung sind weitere bemerkenswerte Aspekte, die sich bereits nach der ersten Einnahme einstellen können. Zur Sicherheit und Wirksamkeit der Komponenten existiert eine Vielzahl von Studien, das Produkt ist seit 2012 unter dem Namen CILTEP (Natural Stacks) in den USA auf dem Markt 

Tagesdosis: 2-5 Kapseln Einnahme vor dem Frühstück, Wirkdauer 10-14 Stunden

 

 

 

Inhaltsstoffe:

 

Artischockenextrakt

Buntnesselextrakt

Acetyl-L-Carnitin

L-Phenylalanin

Vitamin B6

 

Studien zu den Inhaltsstoffen:

Rutten K, Van donkelaar EL, Ferrington L, et al. Phosphodiesterase inhibitors enhance object memory independent of cerebral blood flow and glucose utilization in rats. Neuropsychopharmacology. 2009;34(8):1914-25. PMID 19262466

 

Egawa T, Mishima K, Matsumoto Y, Iwasaki K, Iwasaki K, Fujiwara M. Rolipram and its optical isomers, phosphodiesterase 4 inhibitors, attenuated the scopolamine-induced impairments of learning and memory in rats. Jpn J Pharmacol. 1997;75(3):275-81. PMID 9434259

 

Zhang HT, O'donnell JM. Effects of rolipram on scopolamine-induced impairment of working and reference memory in the radial-arm maze tests in rats. Psychopharmacology (Berl). 2000;150(3):311-6. PMID 10923759

 

Zhang HT, Crissman AM, Dorairaj NR, Chandler LJ, O'donnell JM. Inhibition of cyclic AMP phosphodiesterase (PDE4) reverses memory deficits associated with NMDA receptor antagonism. Neuropsychopharmacology. 2000;23(2):198-204. PMID 10882846

 

Zhang HT, Huang Y, Suvarna NU, et al. Effects of the novel PDE4 inhibitors MEM1018 and MEM1091 on memory in the radial-arm maze and inhibitory avoidance tests in rats. Psychopharmacology (Berl). 2005;179(3):613-9. PMID 15672274

 

Mclean JH, Smith A, Rogers S, Clarke K, Darby-king A, Harley CW. A phosphodiesterase inhibitor, cilomilast, enhances cAMP activity to restore conditioned odor preference memory after serotonergic depletion in the neonate rat. Neurobiol Learn Mem. 2009;92(1):63-9. PMID 19233302

 

Wang C, Yang XM, Zhuo YY, et al. The phosphodiesterase-4 inhibitor rolipram reverses Aβ-induced cognitive impairment and neuroinflammatory and apoptotic responses in rats. Int J Neuropsychopharmacol. 2012;15(6):749-66. PMID 21733236

 

Rose GM, Hopper A, De vivo M, Tehim A. Phosphodiesterase inhibitors for cognitive enhancement. Curr Pharm Des. 2005;11(26):3329-34. PMID 16250839

 

Drott J, Desire L, Drouin D, Pando M, Haun F. Etazolate improves performance in a foraging and homing task in aged rats. Eur J Pharmacol. 2010;634(1-3):95-100. PMID 20223232

 

Li LX, Cheng YF, Lin HB, Wang C, Xu JP, Zhang HT. Prevention of cerebral ischemia-induced memory deficits by inhibition of phosphodiesterase-4 in rats. Metab Brain Dis. 2011;26(1):37-47. PMID 21327879

 

Gallant M, Aspiotis R, Day S, et al. Discovery of MK-0952, a selective PDE4 inhibitor for the treatment of long-term memory loss and mild cognitive impairment. Bioorg Med Chem Lett. 2010;20(22):6387-93. PMID 20933411

 

Heaslip RJ, Evans DY. Emetic, central nervous system, and pulmonary activities of rolipram in the dog. Eur J Pharmacol. 1995;286(3):281-90. PMID 8608790

 

Bruno O, Fedele E, Prickaerts J, et al. GEBR-7b, a novel PDE4D selective inhibitor that improves memory in rodents at non-emetic doses. Br J Pharmacol. 2011;164(8):2054-63. PMID 21649644

 

Mackenzie SJ, Houslay MD. Action of rolipram on specific PDE4 cAMP phosphodiesterase isoforms and on the phosphorylation of cAMP-response-element-binding protein (CREB) and p38 mitogen-activated protein (MAP) kinase in U937 monocytic cells. Biochem J. 2000;347(Pt 2):571-8. 10749688

 

Xu W, Kasper LH, Lerach S, Jeevan T, Brindle PK. Individual CREB-target genes dictate usage of distinct cAMPresponsive coactivation mechanisms. EMBO J. 2007;26(12):2890-903. PMID 17525731

 

Benito E, Valor LM, Jimenez-minchan M, Huber W, Barco A. cAMP response element-binding protein is a primary hub of activity-driven neuronal gene expression. J Neurosci. 2011;31(50):18237-50. PMID 22171029

 

Lee J, Kim CH, Simon DK, et al. Mitochondrial cyclic AMP response element-binding protein (CREB) mediates mitochondrial gene expression and neuronal survival. J Biol Chem. 2005;280(49):40398-401. PMID 16207717

 

Deisseroth K, Bito H, Tsien RW. Signaling from synapse to nucleus: postsynaptic CREB phosphorylation during multiple forms of hippocampal synaptic plasticity. Neuron. 1996;16(1):89-101. PMID 8562094

 

Kida S. A Functional Role for CREB as a Positive Regulator of Memory Formation and LTP. Exp Neurobiol. 2012;21(4):136-40. PMID 23319873

 

Suzuki A, Fukushima H, Mukawa T, et al. Upregulation of CREB-mediated transcription enhances both short- and long-term memory. J Neurosci. 2011;31(24):8786-802. PMID 21677163

 

Ammon HP, Müller AB. Forskolin: from an ayurvedic remedy to a modern agent. Planta Med. 1985;51(6):473-7. PMID 17345261

 

Seamon KB, Daly JW. Forskolin: a unique diterpene activator of cyclic AMP-generating systems. J Cyclic Nucleotide Res. 1981;7(4):201-24. PMID 6278005

 

Barad M, Bourtchouladze R, Winder DG, Golan H, Kandel E. Rolipram, a type IV-specific phosphodiesterase inhibitor, facilitates the establishment of long-lasting long-term potentiation and improves memory. Proc Natl Acad Sci USA. 1998;95(25):15020-5. PMID 9844008

 

Yu MC, Chen JH, Lai CY, Han CY, Ko WC. Luteolin, a non-selective competitive inhibitor of phosphodiesterases 1- 5, displaced [3H]-rolipram from high-affinity rolipram binding sites and reversed xylazine/ketamine-induced anesthesia. Eur J Pharmacol. 2010;627(1-3):269-75. PMID 19853596

 

Brown JE, Rice-evans CA. Luteolin-rich artichoke extract protects low density lipoprotein from oxidation in vitro. Free Radic Res. 1998;29(3):247-55. PMID 9802556

 

Kitagawa Y, Hirano T, Kawaguchi SY. Prediction and validation of a mechanism to control the threshold for inhibitory synaptic plasticity. Mol Syst Biol. 2009;5:280. PMID 19536203

 

Puzzo D, Sapienza S, Arancio O, Palmeri A. Role of phosphodiesterase 5 in synaptic plasticity and memory. Neuropsychiatr Dis Treat. 2008;4(2):371-87. PMID 18728748

 

Otmakhov N, Khibnik L, Otmakhova N, et al. Forskolin-induced LTP in the CA1 hippocampal region is NMDA receptor dependent. J Neurophysiol. 2004;91(5):1955-62. PMID 14702333

 

Piech-dumas KM, Tank AW. CREB mediates the cAMP-responsiveness of the tyrosine hydroxylase gene: use of an antisense RNA strategy to produce CREB-deficient PC12 cell lines. Brain Res Mol Brain Res. 1999;70(2):219-30. PMID 10407170

 

Kumer SC, Vrana KE. Intricate regulation of tyrosine hydroxylase activity and gene expression. J Neurochem. 1996;67(2):443-62. PMID 8764568

 

White HL, Scates PW. Acetyl-L-carnitine as a precursor of acetylcholine. Neurochem Res. 1990;15(6):597-601. PMID 2215852